Dynamic compression of chondrocyte-seeded fibrin gels: effects on matrix accumulation and mechanical stiffness
نویسندگان
چکیده
منابع مشابه
Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels.
Due to its avascular nature, articular cartilage exhibits a very limited capacity to regenerate and to repair. Although much of the tissue-engineered cartilage in existence has been successful in mimicking the morphological and biochemical appearance of hyaline cartilage, it is generally mechanically inferior to the natural tissue. In this study, we tested the hypothesis that the application of...
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Collagen and fibrin are important extracellular matrix (ECM) components in the body, providing structural integrity to various tissues. These biopolymers are also common scaffolds used in tissue engineering. This study investigated how co-gelation of collagen and fibrin affected the properties of each individual protein network. Collagen-fibrin co-gels were cast and subsequently digested using ...
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Introduction: Natural biomaterials and growth factors are key factors in tissue engineering. The objective of the present study was to evaluate transforming growth factor beta 1 (TGF-β1) and curcumin on proliferation and differentiation of nasal-derived chondrocyte seeded on the fibrin glue scaffold. Methods: Chondrocytes were isolated from nasal samples. Nasal-derived chon...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2004
ISSN: 1063-4584
DOI: 10.1016/j.joca.2003.08.009